Y-Globin

Wang G., Xu X., Pace B., Dean D.A., Giazer P.M., Chan P., Goodman S.R., Shokolenko I. Peptide nucleic acid (PNA) binding-mediated induction of human y-globin gene expression. Nucleic Acids Res. 1999, 27 2806-2813. 

Fetal hemoglobin (HbF), which has slightly different Oj binding properties from HbA, is composed of two a- and two y-globin subunits. 

A dominant theme in the treatment of sickle cell disease is the manipulation of the hemoglobin switch from fetal to adult hemoglobin. If the switch did not occur at all or if the y-globin gene did not completely switch to P-globin... 

Lampronti, 1., Bianchi, N., Borgatti, M., Fibach, E., Prus, E. and Gambari, R. (2003) Accumulation of y-globin mRNA in human erythroid cells treated with angelicin. Eur. J. Haematol., 71,189-95. 

ZF VP64 y-globin promoter Cell culture (Endogenous gene) Sickle cell disease (2)... 

Hb Bart s. Hb Bart s results from deletion of aU four a-globin genes with the subsequent inability to produce any a-globin chains that leads to failure of synthesis of Hbs A, F, or A2. In the fetus there is an excess of y-globin chains that join together to form unstable tetramers known as Hb... 

Fig.4 Effects of angelicin (white boxes) on HbF production (A) and y-globin mRNA expression (B). HbF was analysed by HPLC, y-globin mRNA accumulation by real-time quantitative RT-PCR. The effects of angelicin were compared to those of hydroxyurea (black boxes-, grey box = control untreated cells)...

Firan M, Bawdon R, Radu C, Ober RJ, Eaken D, Antohe F, Ghetie V, Ward ES. The MHC class I-related receptor FcRn, plays and essential role in the matemofetal transfer of y-globin in humans. Int Immunol 2001 13 993-1002. 

Recent data, however, contradict Rabat s hypothesis. DNA complementary to y-globin mRNA was synthesized with the aid of an avian virus reverse transcriptase. Hybridization of this DNA with DNA of differentiating erythroblast cells of humans showed that the DNA of these cells has y-globin genes (Mitchelfand Williamson, 1977). The presence of genes for and y-globins was found in sheep... 

In the first report on phylogenetic footprinting [4], e-globin and y-globin sequences from 10 species were compared, which yielded several regions of high sequence conservation over 70 Myr. A number of these regions has subsequently been shown to contain cis-elements involved in the expression of... 

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