Xenobiotics biological effects

Ideally, biomarkers of exposure should have a direct and quantitative relationship to the xenobiotics biologically effective dose. This term refers to the internal dose of xenobiotic that produces a predictable biologic... 

A biomarker of susceptibility is an indicator of an inherent or acquired limitation of an organism s ability to respond to the challenge of exposure to a specific xenobiotic substance. It can be an intrinsic genetic or other characteristic or a preexisting disease that results in an increase in absorbed dose, a decrease in the biologically effective dose, or a target tissue response. If biomarkers of susceptibility exist, they are discussed in Section 3.10 Populations That Are Unusually Susceptible. 

Xenobiotics can produce a variety of biologic effects, including pharmacologic responses, toxicity, immunologic reactions, and cancer. 

Britvic, S., D. Lucic, and B. Kurelec. 1993. Bile fluorescence and some early biological effects in fish as indicators of pollution by xenobiotics. Environ. Toxicol. Chem. 12 765-773. 

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