Xanthone-a-mangostin

Nakatani K, Norimichi N, Tsutomu A, Hideyuki Y, Yasushi O. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by -y-mangostin, a xanthone derivative in man-gosteen, in C6 rat glioma cells. Biochem Pharmacol 2002 63 73-79. 

A total of 515 xanthones have been identified in 20 families of higher plants, mainly in the Bonnetiaceae and Clusiaceae families (Vieira and Kijjoa 2005). Mangosteen fruit, a typical southeast Asian fruit, is the characteristic dietary source of xanthones (less than 7-8 mg/100 g FW) (Walker 2007). Mangostin is a C-glucosylxanthone that is also found in by-products of mango at high concentration levels (Barreto and others 2008). 

In 1993, a new xanthone paxanthone (27) was isolated with toxyloxanthone B (28) and y-mangostin (29) from the eell suspension cultures in the callus tissue cultures of Hypericum patulum (Figure 7a) [21],... 

In 2012, a group of Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, and Center of e-CAM, Taipei Medical University, Taiwan examied the apoptotic effects of a xanthone derivative y-mangostin (29) on the colorectal adenocarcinoma cells HT29 cells. 

In 2005, six xanthones such as y-mangostin (29), garcinone (31), patulone (38), 1,3,5,6-tetrahydroxyxanthone (39), patuloside A (41) and patuloside B (42) from Hypericum patulum were examined on their inhibitory effect at a dose of 10 mg/kg were orally administered 1 hour before injection with exogeneous platelet activating factor (PAF) 10 pg/kg against the exogeneous... 

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