World Health Organization, acceptable daily toxicant dose

The acceptable daily dose of a toxicant (in mg/(kg x day)), D-j, relative to chronic human health effects, is central to PPLV calculations. Table II lists seven sources of information from which D.j values may be drawn. From this, it is seen that, if there is available an ADI (Acceptable Daily Intake) value originating with the World Health Organization (7), then that figure should be used as Qj. 

Interspecies and intraspecies UFs have been used in the development of safe or threshold exposure levels for chronic, noncancer toxicity by health organizations throughout the world. Examples include the acceptable daily intake (ADI) (Lu 1988 Truhaut 1991 Lu and Sielken 1991), the tolerable daily intake (TDI) or tolerable concentration (TC) (Meek et al. 1994 IPCS 1994), the minimal risk level (MRL) (Pohl and Abadin 1995), the reference dose (RfD) (Barnes and Dourson 1988 Dourson 1996), and the reference concentration (RfC) (EPA 1994 Jarabek et al. 1990). The importance of using distribution-based analyses to assess the degree of variability and uncertainty in risk assessments has been emphasized in recent trends in risk analysis. This will enable risk managers to make more informed decisions and... 

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