Withdrawal state heroin

Naloxone may precipitate a severe withdrawal state in abusers of opioid analgesics with symptoms starting in less than 15-30 minutes Methadone alleviates most of the symptoms of heroin withdrawal A young male patient is brought to the emergency room of a hospital suffering from an overdose of cocaine following intravenous administration. His symptoms are unlikely to include... 

Cocaine (281) when sniffed or injected gives rise to a state of euphoria often followed by paranoid delusions. Although there are no withdrawal symptoms, as it does not cause physical dependence, it probably does more harm to brain and body than any other drug (282). There is a good case for its total prohibition, as it no longer serves any essential medical purpose, and, unlike heroin, there is no readily available natural source from which it may be manufactured. 

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