Withdrawal state amphetamine

Auditory unformed tinnitns, whistles formed voices, often insulting or accusatory - benzodiazepine withdrawal - cocaine, amphetamine, alcoholic hallucinosis, drug induced deliria and psychotic states... 

The literature on a withdrawal syndrome (SEDA-10, 17) has been expanded by further reports. One of these (33) involved the development of an acute toxic delirium 3 days after withdrawal of phenelzine, and another (34) concerned patients who became manic after withdrawal of isocarboxazid. A withdrawal state similar to that caused by withdrawal from amphetamines has been described after withdrawal of tranylcypromine (SEDA-16, 8) (SEDA-18,14). 

There are no proven pharmacotherapies for treatment of cocaine or amphetamine dependence. Disulfiram, however, shows some promise in randomized controlled trials for treating cocaine dependence at doses of 250 mg daily, especially in combination with CBT.45 Its mechanism of action for treating cocaine dependence is not known, but may be due to its inhibition of the dopamine P-hydroxylase enzyme that converts DA to NE in the brain. The resulting increase in DA levels may counter the DA-deficient state that is believed to underlie cocaine withdrawal and craving. 

Sibutramine (Meridia), a weight-loss drug introduced in 1998, inhibits the reuptake of the brain chemicals norepinephrine, dopamine, and serotonin, but does not promote monoamine release like the amphetamines. Yet the drug has been linked to serious side effects, including rapid heart rate, increased blood pressure, heart disease, stroke, seizure, and mental impairments. In March 2002, Italy s Health Ministry announced that it was immediately withdrawing all sibutramine products from the market due to health-related problems. Also, Meridia was the subject of a class action lawsuit filed in the United States. 

So the paranoid psychosis produced by cocaine and amphetamine overdose is properh called stimulant psychosis. By the late 1960s, the word was out on the street— Speed kills What was referred to in this slogan was not just death by overdose. Amphetamine overdose deaths did occur, but they were relatively rare. Far more common was the development of a paranoid state that often led to acts of violence. In addition, after a long binge of amphetamine abuse, the user may crash (sleep for an extended period) and then awaken deeply depressed. The depression could last for days and is now recognized as a common withdrawal symptom after hca%7 use of either amphetamine or cocaine. The depression often leads the user back to drugs to try to get up again, and the cycle is repeated. Eventually the user s physical and mental health deteriorates badly unless he or she can break out of the cycle. 

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