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Withanolide antitumor activity

Hydroxy group along with 58,66-epoxy system is essential for the antitumor activity, eg. withanolide E (46), 48-OH withanolide E (53). Thus 17-isowithanolide (34) possessing 17 -OH... [Pg.245]

The antitumor potential of withanolides has been extensively investigated by the researchers all around the world, which led to the identification of diverse properties such as cytotoxicity, cell differentiation induction, cancer chemoprevention, and COX-2 and quinine reductase enzymes inhibition potential of withanolides. Recently, over 80,000 natural and synthetic compoxmds were evaluated by Santagat and coworkers for their anticancer activity, targeting protein homeostasis. They concluded that many active compoxmds were natxxral products belonging to the five classes, limonoids, celastraloids, coUetofiragarones, curvularins, and withanolides [65]. [Pg.3477]

Table 114.2 A list of pharmacologically active withanolides, other than antitumor/anticancer ... Table 114.2 A list of pharmacologically active withanolides, other than antitumor/anticancer ...
See other pages where Withanolide antitumor activity is mentioned: [Pg.521]    [Pg.704]    [Pg.3466]    [Pg.3466]    [Pg.3467]    [Pg.3469]    [Pg.3471]    [Pg.3473]    [Pg.3477]    [Pg.3479]    [Pg.3479]    [Pg.3480]    [Pg.3481]    [Pg.3483]    [Pg.3485]    [Pg.3485]    [Pg.3485]    [Pg.3487]    [Pg.3487]    [Pg.3488]    [Pg.3489]    [Pg.3491]    [Pg.3493]    [Pg.3496]    [Pg.423]    [Pg.423]    [Pg.143]    [Pg.423]    [Pg.1020]    [Pg.2740]    [Pg.2786]    [Pg.3465]   
See also in sourсe #XX -- [ Pg.19 , Pg.470 ]

See also in sourсe #XX -- [ Pg.19 , Pg.470 ]



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Antitumor activity

Antitumoral activity

Withanolide

Withanolides

Withanolides activity

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