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Whole-organism screening

In summary, our data provide evidence for the suitability of zebrafish eleuther-oembryos as a predictive vertebrate model for evaluating the effect of individual chemicals and mixtures on thyroid gland function. TIQDT performed on zebrafish eleutheroembryos is an alternative whole-organism screening assay that provides relevant information for environmental and human risk assessments. [Pg.430]

Whole-Organism Screening for Modulators of Fasting Metabolism Using It ansgenic Zebrafish... [Pg.157]

Lemieux GA et al (2011) A whole-organism screen identifies new regulators of fet storage. Nat Chem Biol 7 206-213... [Pg.165]

Gut P et al (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol 9 97-104... [Pg.165]

The in vitro screening methods have several advantages over in vivo testing such as the undisputable ethical benefits, a lower cost, and a shorter time to perform the study. Moreover, in vitro methods offer the possibility to identify and investigate specific toxicity mechanisms (such as oxidative stress, pathways involved in NM intracellular uptake, genotoxicity) in a relatively simple system, without the complexity and interferences of several factors present in vivo in a whole organism. [Pg.482]

See other pages where Whole-organism screening is mentioned: [Pg.163]    [Pg.581]    [Pg.288]    [Pg.68]    [Pg.132]    [Pg.133]    [Pg.15]    [Pg.157]    [Pg.163]    [Pg.163]    [Pg.581]    [Pg.288]    [Pg.68]    [Pg.132]    [Pg.133]    [Pg.15]    [Pg.157]    [Pg.163]    [Pg.316]    [Pg.346]    [Pg.194]    [Pg.113]    [Pg.281]    [Pg.298]    [Pg.88]    [Pg.167]    [Pg.104]    [Pg.111]    [Pg.15]    [Pg.45]    [Pg.325]    [Pg.325]    [Pg.329]    [Pg.521]    [Pg.280]    [Pg.104]    [Pg.247]    [Pg.314]    [Pg.29]    [Pg.137]    [Pg.258]    [Pg.1432]    [Pg.1724]    [Pg.53]    [Pg.872]    [Pg.2635]    [Pg.18]    [Pg.134]    [Pg.152]    [Pg.297]    [Pg.136]    [Pg.96]   
See also in sourсe #XX -- [ Pg.68 ]



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Whole organism

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