Weight gain pioglitazone

Thiazolidinediones15 Pioglitazone 15-45 mg by mouth daily rosiglitazone 4-8 mg by mouth daily Weight gain increase in total, LDL, and HDL cholesterol edema headache fatigue hepatic injury (rare)... 

In 244 patients with type 2 diabetes who took pioglitazone 30 or 45 mg/day for 20 weeks or 30 mg/day for 12 weeks and then 45 mg/day for 8 weeks, blood pressure, liver enzymes, and lipid profile improved and HbAlc fell by 1% (25). There was one serious adverse effect related to pioglitazone severe headache and severe weight gain in a patient taking 30 mg/day, which required drug withdrawal. 

Thiazolidinediones cause recruitment and conversion of pre-adipocytes into adipocytes and are therefore adi-pogenic (75). In 18 patients without diabetes, mean age 46 years, who took pioglitazone 30 mg/day for 48 weeks for non-alcoholic steatohepatitis, there was a mean weight gain of 3.5 kg in 72% (76). Similarly, in 91 patients with type 2 diabetes who took pioglitazone 30 or 45 mg/day for... 

However, in 23 patients who took pioglitazone for 16 weeks, in whom fasting and mean glucose concentrations and mean free fatty acid concentrations fell, weight gain of 3.6 kg was associated with an increase in peripheral fat without edema (81). 

Pioglitazone, is indicated once daily in patients not controlled by metformin alone. It is contraindicated by cardiac or hepatic failure. Weight gain and oedema are the main adverse effects. 

The most commonly reported adverse events with both pioglitazone and rosiglitazone were upper respiratory tract infection and headache, although other side effects include abnormal liver function, edema, weight gain, and anemia. 

In a recent report, patients with a shorter duration of diabetes and higher body mass index were significantly more likely to gain weight on pioglitazone therapy [66],... 

King AB, Armstrong D. Characteristics of the patients who gain weight while on pioglitazone treatment [abstract 481-P]. Diabetes. 2001 50(suppl 1) A120. 

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