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Water partitioning system

The liquid junction potential from the organic side may be negligible, owing to the use of a nitrobenzene-water partition system containing tetraethylammonium picrate as the salt bridge. The mobilities of both ions in nitrobenzene are similar, and they have similar Gibbs energies of... [Pg.45]

Chiou chose glyceryl trioleate (triolein) as model lipid because of its similarity to triglycerides which are abundant in organisms [109], Triolein is also a bulk lipid and the good correlation with the bioconcentration factor is restricted to neutral compounds of moderate hydrophobicity. No attempts were made to measure partitioning of ionogenic compounds with the glyceryl trioleate-water partition system. [Pg.218]

Often we may want to quantitatively extrapolate our experience with one organic solvent-water partitioning system to know what to expect for new systems. This is typically done using a linear free energy relationship of the form ... [Pg.218]

Ideally, biphasic catalysis is performed in such a way that mass-transfer from one phase to the other does not restrict the rate of the reaction. An elegant solution to overcome this potential limitation is reversible two phase-single phase reaction conditions. An example of a temperature-controlled reversible ionic liquid-water partitioning system has been demonstrated for the hydrogenation of 2-butyne-l,4-diol, see Figure 3.2.1251... [Pg.46]

Fujiwara, H., Da, Y.-Z., Ito, K., Takagi, T., Mishioka, Y. (1991) The energy aspect of oil/water partition and its application to the analysis of quantitative structure-activity relationship. Aliphatic alcohols in the liposome/water partition system. Bull. Chem. Soc. Jpn. 64, 3707-3712. [Pg.325]

However, whether the effects of ionization in the octanol- water partition systems in HPLC and TLC are simila remains to be clarified. The stationary phase materia and, especially the presence of the acidic silanol sites, may have an active role. Moreover, concerning the twcP... [Pg.194]

These possible steric effects have been evaluated by an approach involving partition coefficients. In this way, an estimate of comparative lipophilicity can be made since this property is felt to influence the ease of membrane transport and thus eventual availability to the site of action. A number of psychotomimetic phenylisopropylamines have been studied in an octanol-water partition system, and the correlation of the resulting values, with central activity has provided a relationship that suggests an optimum lipophilicity for maximum biological activity (Barfknecht et al. 1975). These partition values have been correlated to serotonin receptor stimulation capability (Nichols and Dyer 1977) and have recently been extended to a number of phenethylamine compounds (Nichols et al. 1977). [Pg.6]

With this representation in mind, a partial explanation can bc presented as to why the /i-octanol/water partitioning system seems to mimic the lipid mcmbranc.s/watcr sy.stctns found in the body. It turns nut that /i-octanol is not as nonpolar as initially might be predicted. Water-saturated octanol contains 2..1 M water because the small water molecule easily clusters around oclunoTs hydroxy moiety. -Ocianol-satur-ated water contains little of the organic phase bccau.se of the large hydrophobic 8-carbon chain of octanol. The water in the /t-octanol phase apparently approximates the polar prop-... [Pg.19]

Headspace methods involving adsorption of volatiles onto porous polymer traps have also been developed (41-45). Another technique, in which volatiles are entrained into a Freon Fll/water partition system (46), has been found to have good reproducibility for a range of wine volatiles (47). The Freon Fll extract obtained by this technique can be concentrated at low temperature to give aroma concentrates essentially free from water and ethanol. [Pg.232]

Log D membrane, or log D em/ is another way of measuring the lipophilicity of a compound, which is less frequently used than the octanol/water partition system. Log Dmem utilizes liposomes prepared from the synthetic phospholipids dimyristoylphosphatidylcholine (DMPC), and although the system is more physiologically relevant than octanol, it suffers from a lack of predictability. This method requires 1 mg of the compound, whereby a solution of the compound is equilibrated with a solution of DMPC liposomes at 37°C for two hours. The free and liposome-bound compounds are then separated by centrifugation, and the solutions are analyzed by high-performance liquid chromatography (HPLC). [Pg.107]

Table 1.1 Advantages and disadvantages of using the 1-octanol/water partitioning system as a reference scale. Table 1.1 Advantages and disadvantages of using the 1-octanol/water partitioning system as a reference scale.
However, whether the effects of ionization in the octanol-water partition systems in HPLC and TLC are similar remains to be clarified. The stationary phase material and, especially the presence of the acidic silanol sites, may have an active role. Moreover, concerning the two chromatographic techniques, even in the case of identical stationary phases, an essential difference between HPLC and TLC is the fact that, in HPLC, the column is equilibrated with the mobile phase before runs are conducted. Thus the stationary phase is adjusted to the mobile phase pH, whereas on a TLC plate, a pH gradient is formed. [Pg.1402]

H. Fujiwara, Y. Z. Da, K. Ito, T. Takagi, and Y. Nishioka, Bull. Chem. Soc. japan, 64, 3707 (1991), The Energy Aspect of Oil/Water Partition and Its Application to the Analysis of Quantitative Structure-Activity Relationships. Aliphatic Alcohols in the Liposome/Water Partition System. [Pg.305]


See other pages where Water partitioning system is mentioned: [Pg.388]    [Pg.416]    [Pg.70]    [Pg.316]    [Pg.156]    [Pg.257]    [Pg.461]    [Pg.16]    [Pg.532]    [Pg.586]    [Pg.320]    [Pg.498]    [Pg.128]    [Pg.22]    [Pg.5]    [Pg.308]   


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