Water for manufacturing

Fabrikations-gangt m. manufacturing process, processing. -prozess, m. manufacturing process, -wassert n. water for manufacturing use. 

Sampling and testing of water for manufacturing or final rinsing at least once a day. All sampling ports or points of use in the distribution system shall be sampled at least weekly. 

Final fdters of water for injectable products may not be used at any point in the piping system of water for manufacturing or final rinse. 

Pipelines for the transmission of water for manufacturing or final rinse and other liquid components shall be constructed of welded stainless steel (nonrusting grade) equipped for sterilization with steam, except that sanitary stainless steel lines with fittings capable of disassembly may be immediately adjacent to the equipment or valves that must be removed from the lines for servicing and replacement. 

The BLA should include information for systems used in the production of water for manufacturing and rinsing of product-contact equipment. This subsection should include a general description of water system(s), a validation summary, and information on the routine monitoring program. 

A commercial design based on semicontinuous operation was developed for manufacture of silicate powders (27). A slurry, prepared containing the feed materials and water, is fed to the reactor tank and heated by circulating a heat-exchange fluid in channels located on the outside vessel wall. A six-bladed stirrer is operated at about 100 rpm in order to keep reagents well mixed. Once the slurry reaches the operating temperature, the vessel heat is maintained until reaction is complete. For most fine-particle products, this time is less than 1 hr. 

Naphthaleneamine is a dye intermediate and is used as the starting material in the manufacture of the rodenticide, Antii (8), l-naphthalenethiourea/5 %< < -4/, which is prepared by heating a mixture of 1-naphthylamine hydrochloride, NH SCN, and a large amount water for 14—16 h while keeping its volume constant by a dding an additional amount of water, to give a 97% yield. Its LD q is 600 mg in squirrels (46). 

Available Forms. Phthalocyanines are available as powders, in paste, or Hquid forms. They can be dispersed in various media suitable for aqueous, nonaqueous, or multipurpose systems, eg, polyethylene, polyamide, or nitrocellulose. Inert materials like clay, barium sulfate, calcium carbonates, or aluminum hydrate are the most common soHd extenders. Predispersed concentrates of the pigments, like flushes, are interesting for manufacturers of paints and inks (156), who do not own grinding or dispersing equipment. Pigment—water pastes, ie, presscakes, containing 50—75% weight of water, are also available. 

The monomers, butadiene (qv) and styrene (qv), are the most important ingredients in the manufacture of SBR polymers. For ESBR, the largest single material is water for solution SBR, the solvent. 

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