Warrants sense

For the accumulated costs and resources devoted to the development of a new chemical entity (NCE) or new molecular entity (NME) to make sense financially, the commercial potential of the compound must be evaluated in a rigorous manner. Compounds whose expected financial performance does not warrant these high investment costs must be abandoned or out-licensed as soon as possible so as to direct resources toward more profitable endeavors. By operating effectively, a well-designed drug discovery and development process can focus its efforts to operate efficiently on the compounds that will maximize cash flow to the pharmaceutical firm. 

If the relapse is due to nonadherence that resnlted from poor insight (either on the part of the patient or his/her friends and family), then an aggressive psychosocial intervention is warranted. Again, it often makes sense to continne the same medication in this scenario. If poor insight remains a problem, then serions consideration should be given to a depot form of antipsychotic. 

In the early 1970 s, the American Chemical Society authorized an alternative system for naming fully fluorinated compounds or groups in which the symbol F conveys the sense of perfluoro . This system, which has its roots in phi-nomenclature (e.g., (/(-heptane is 1) proposed in the 1940s, has not been used widely enough to warrant adopting it in this book. According to -nomenclature, for example, 2 is F-ncopcntanc, 3 is F-propene, 4 is F-pro-panal, 5 is bromo-F-benzene, and 6 is ethyl F-ethyl ether. 

Our previous work with PPNVP and GOx-PPNVP/PEUU (6,12,25), which focused on characterization of the surface modified thin films, has demonstrated that a reasonable amount of control can be exerted over the chemistry of plasma modification. The techniques used here to attach active GOx to PEUU may be applied to a wide variety of biomolecules and a wide variety of organic and inorganic substrates. Incorporation of GOx-PPNVP/PEUU into the thin-layer cells extended the potential applicability of GOx-PPNVP/PEUU and similar materials to specific practical applications such as sensing devices. Similarly, the ease of fabrication of the thin-layer cells and the wide variety of electrochemical techniques which are available for use with thin-layer cells warrant further development of this system. 

The monocyclic substrates are well suited for discussion of relative stereocontrol. In a recently reported study employing cis- and rrar -disubstituted substrates (9) and (10). high stereoselectivity could be obtained when gallium trichloride was used as the Lewis acid (Scheme 12). In these reactions new stereocenters can be created at C(3) and C(3a). In the cis series both tautomeric products were formed as single stereoisomers while the trans series (10) produced a mixture of the tetrasubstituted isomers. A post facto epimerization was suggested as the cause for the lower selectivity. Discussion of the rotational sense is not warranted here as the configurations of the newly created centers were not rigorously established. 

Although intermittent experiences of boredom are to be expected during adolescence, and although constructively coping with this sense of aimlessness is an important responsibility to learn, days of a child feeling bored, like days of feeling depressed, warrant parental attention and intervention. 

A brief review of Ln coordination chemistry is warranted as a precursor to appreciating the structural systematics of extended solids comprised thereof. In addition, this section aims to exemplify a number of Ln-specific properties and coordination preferences with the goal of distinguishing these materials from transition metal MOFs and CPs. It is felt that there are a number of attractive features of the/-elements (specifically their luminescent behavior) that make Ln-MOFs potentially more appropriate for certain applications (e.g., sensing). 

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