Warfarin induced coagulopathies

Factor IX complex In a retrospective chart review of 28 patients treated with intravenous factor IX complex for warfarin-induced coagulopathy, the INR was reduced from 5.1 to 1.9 within a mean of 14 minutes there were no early thrombotic events or allergic reactions [67 ]. 

Wojcik C, Schymik ML, Cure EG. Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy. Int J Emerg Med 2009 2(4) 217-25. 

Patients at increased risk of NSAID-induced gastrointestinal adverse effects (e.g., dyspepsia, peptic ulcer formation, and bleeding) include the elderly, those with peptic ulcer disease, coagulopathy, and patients receiving high doses of concurrent corticosteroids. Nephrotoxicity is more common in the elderly, patients with creatinine clearance values less than 50 mL/minute, and those with volume depletion or on diuretic therapy. NSAIDs should be used with caution in patients with reduced cardiac output due to sodium retention and in patients receiving antihypertensives, warfarin, and lithium. 

Nemoto C, Ikegami Y, Shimada J, Tsukada Y, Abe Y, Tase C. Acute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin a case report. J Anesth 2012 26(6) 943-4. 

Intracranial bleeding after TBI can be further exacerbated by coagulopatiiies, which develop in up to one-third of TBI patients (Zehtabchi et al., 2008 Allard et al., 2009 Wafaisade et al., 2010). Coagulopathies may result either from xmderl37ing anticoagulation medications (e.g., warfarin, clopidogrel) or from TBI-induced platelet dys-fxmction, release of systemic tissue factor, and activation... 

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