Warfarin Broccoli

Drug/Food interactions Vitamin K-rich vegetables may decrease the anticoagulant effects of warfarin by interfering with absorption. Minimize consumption of vitamin K-rich foods (eg, spinach, seaweed, broccoli, turnip greens) or nutritional supplements. Mango has been shown to increase warfarin s effect. 

The authors did not propose a mechanism for this interaction, although the rapidity of the effect suggests protein binding displacement of warfarin nor did they comment on the possible role of the extract of broccoli, which contains vitamin K. 

Monterrey-Rodrigues et al., 2002). Because bromelian in papaya and pineapple modulates the arachidonate cascade, INR rates are also increased with concomitant use of warfarin (Shaw et al., 1997). In contrast, the vitamin K in a variety of green vegetables, particularly broccoli, in large amounts can act as an antagonist to the effects of anti-coagulant therapy (D Arcy, 1993) in warfarin overdose, vitamin K is used to normalize the INR. 

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