Wajima method

Wajima and coauthors offer an alternative approach to utilize animal VD data to predict human VD [13]. Several compound descriptors that included both chemical structural elements as well as animal VDSS values were subject to multiple linear regression and partial least squares statistical analyses, with human VDSS as the independent parameter to be predicted using a dataset of 64 drugs. Methods derived in this manner were compared to simple allometry for overall accuracy. Their analyses yielded the following regressions ... 

Prediction of Plasma Concentration-Time Profile by Using the Wajima Allometric Method... 

The Wajima aUometric method is used to extrapolate to human the plasma concentration-time profiles observed in vivo in each preclinical species (Wajima et al., 2003 VuppugaUa et al., 2011). Dose normaUzed curves are obtained by dividing the time axis with mean residence time (MRT set equals to V /CL) and the concentration axis with dose/V (CJ of the respective preclinical species. The plasma lime course in humans after IV administration can be simnlated using the normalized curve of the precUnical species and the predicted values of and CL in humans, hi other words, this... 

FIGURE 6.1 Illustration of the principle of the methods of Wajima allometry (a) and PBPK model (b) used to predict concentration-time profiles in a standard human, (a) Adapted from Vuppugalla et al. (2011, pp. 4111-4126). (b) Adapted from Yoon et al. (2012, pp. 633-652) and Poulin et al. (2015b). 

TABLE 6.1 Principal Studies Related to the Wajima Allometry and PBPK Modeling Methods... 

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