Vomiting selective serotonin receptor inhibitors

Dexamethasone has been nsed successfully in the management of chemotherapy-indnced and postoperative nansea and vomiting, either as a single agent or in combination with selective serotonin receptor inhibitors (SSRIs). For chemotherapy-indnced nansea and vomiting, dexamethasone has demonstrated efficacy in the prevention of both cisplatin-indnced acnte emesis" and delayed nansea and... 

NVP nausea and vomiting of pregnancy PONV postoperative nausea and vomiting RINV radiation-induced nausea and vomiting SSRI selective serotonin receptor inhibitor... 

Litoxetine is a new selective and potent inhibitor of serotonin receptors that has antiemetic effects against cisplatin-induced emesis. The clinical use of the majority of sero-toninergic antidepressants such as fluoxetin and fluvoxamine is associated with gastrointestinal discomfort which appears to be due to stimulation of 5-HT3 receptors. Litoxetine, by antagonizing 5-HT3 receptors, may limit nausea and vomiting associated with fluoxetin or fluvoxamine (see also Figure 73). 

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