Vomiting, local anesthetic toxicity

SAFETY PROFILE Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also QUININE. 

Toxicoiogy LD50 (oral, rat) 1300 mg/kg, (IP, mouse) 9 mg/kg, (subcut., rabbit) 5000 mg/kg highly toxic poison by Ing. and IP routes allergen feeble local anesthetic skin and eye Irritant vapors can Irritate nose, throat, lungs CNS depressant (nausea, vomiting, headache, dizziness, abdominal pain) 1 g/kg may be fatal In humans mutagenic data TSCA listed... 

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