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Voltage-gating functional properties

Kv 3 -subunits are auxiliary subunits of Shaker-related Kv-channels, which belong to the Kvl subfamily of voltage-gated potassium channels. Kv(3 -subunits may function as chaperones in Kva -subunit assembly and may modulate the gating properties of Kv-channels. In particular, some Kv(3 -subunits may confer a rapid inactivation to otherwise non-inactivating Kv-channels. [Pg.677]

Ion channels are macromolecular complexes that form aqueous pores in the lipid membrane. We have learned much about ion channel function from voltage clamp and patch clamp studies on channels still imbedded in native cell membranes [1-6, 8]. A diversity of channel types was discovered in the different cells in the body, where the repertoire of functioning channels is adapted to the special roles each cell plays [5]. The principal voltage-gated ones are the Na+, K+ and Ca2+ channels, and most of these are opened by membrane depolarizations. Figure 6-5A summarizes the major functional properties of a voltage-gated... [Pg.99]

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Functional properties

Gate function

Gate voltage

Properties gating

Voltage-gated

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