Vitamin treatment

A. G. Bostom, D. Shemin and K. LaPane, High Dose B-Vitamin Treatment of Hyperhomocysteinemia in Dialysis Patients, Kidney International 49 (1996) 147-152. 

Yoburn D, Nadeau MR, et al. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int 1996 49 147-52. 

Patients with homozygous sickle cell disease (SS) had a mean serum folate of 5.8 JLg/liter compared with 7.2 p.g/liter in patients with sickle cell trait and 7.9 p.g/liter in healthy controls. However, there was no correlation between the serum folate and the hematocrit or reticulocyte count. Since reticulocytes may have a higher folate concentration than mature erythrocytes, Liu found that the erythrocyte folate, measured before and after removal of the reticulocytes, was a reliable indicator of the folate status in patients with sickle cell disease despite the variable degree of re-ticulocytosis. Using this technique only one of nine patients was found to have a low erythrocyte concentration of the vitamin. Treatment with fohc acid resulted in higher hematocrits in three of four patients with low serum and erythrocyte folate concentrations, but only one of 12 patients with a normal folate concentration showed any improvement when treated with folate. 

Sdavlt Richter. (Dr.KurtRichtin Hen-kd/C0s dia] Muldvitamin ieibalcom-iriex vitamin treatment for skin and hdr care prods. 

Soluvit Richter. [Dr. Kurt Richter Hen-kd/Cospha] Multivitamin-herbal complex vitamin treatment for ddn and hair care prods. 

Compare the vitamin treatment of methylmalonicaciduria with that of cystathioninuria. Why are these treatments used ... 

Clarke, R., Halsey, J., Lewington, S., Lonn, E., Armitage, J., Manson, J.E., Bonaa, K.H., Spence, J.D., Nygard, O., Jamison, R., Gaziano, J.M., Guarino, P., Bennett, D., Mir, F., Peto, R., and Collins, R., 2010. B-Vitamin Treatment Trialists Collaboration. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, caneer, and cause-specific mortality meta-analysis of 8 randomized trials involving 37485 individuals. Archives of Internal Medicine. 170 1622-1631. 

Further studies are needed to fully assess the risks/benefits with B vitamins treatment in various groups of patients with cardiovascular disease. 

The pre-treatment plasma folate concentration was substantially higher in fortified populations compared with that in non-fortified populations, and allocation to B vitamin treatment was associated with a greater proportional reduction in homocysteine concentrations in non-fortified compared with that in fortified populations (Clarke et al. 2010). The meta-analysis assessed the effects of B vitamins on risk of vascular and non-vascular events assodated with about a 25% reduction in homocysteine levels for about five years (Clarke et al. 2010). 

Among the 50 378 participants in ten trials with CHD events, there were 4516 CHD events one trial did not report results for CHD events (Baker et al. 2002). Figure 45.1 shows that allocation to B vitamin treatment had no significant effect on risk of CHD events (either benefidal or hazardous) with 2282 events... 

B-Vitamin Treatment Trialists Collaboration, 2006. Homocysteine-lowering trials for prevention of cardiovascular events a review of the design and power of the large randomized trials. American Heart Journal. 151 282-287. 

Observations on 15 infants with vitamin D intoxication after high doses of vitamin D (1-25.2 Mio. units given over a period as short as one month and as long as 4 months (49 -) have been reported. The authors of this paper, from the Lebanon, stress once more the fact that, particularly in developing countries, cases of vitamin D toxicity in children continue to occur because of the public demand for parenteral vitamin treatment, despite the fact that paediatricians are well aware of the risks. 

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