Viscosity detectors experimental conditions

A viscometric detector together with a concentration detector can provide information on molar masses of macromolecules emerging from the FFF system [76,134,142-144] using the Mark-Houwink-Kuhn-Sakurada coefficients. If these coefficients are not available, an intrinsic viscosity distribution can still be determined without calibration. Detailed features of this distribution are unique to a given polymer sample, and are not affected by changes in experimental conditions [145]. In fact, since the intrinsic viscosity distribution is more directly related to end-use properties, its measurement is preferred in certain applications. 

Eq. 1 predicts that the average droplet size depends on the gas and solvent flow rate. It also predicts that the average droplet size will depend on the namre of the solvent, because of the dependency on the density, surface tension, and viscosity of the nebulized liquid. The initial droplet size formed in the nebuhzer has little to do with the property of the analyte as it predominantly contains mobile phase. The final droplet size in the scattering chamber is dependent on the analyte concentration. When optimizing detector conditions, the experimental parameters that can be adjusted are nebulizer gas flow rate, mobile phase flow rate, and drift mbe temperature. 

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