Virus Sialidase Substrate Binding and Active Site

Influenza Virus Sialidase Substrate Binding and Active Site 

The X-ray crystal structure of virus sialidase was first solved in early 1980s.24,25 While the active site could be identified, resolution was insufficient to determine the orientation of the bound ligand (Neu5Ac) within the catalytic center. Subsequent efforts in protein crystallography allowed further refinement 

Key active site residues occupy similar positions, with only minor variation in the position of Glu276 in S5 and some bound water molecules evident among the different subtypes. 

---