Virulence of bacteria

Capsular polysaccharides are actively involved in the mediation of complement, in that they are able to suppress the activation of the immediate, alternative-pathway mechanism, thus forcing the immune system to use the classical pathway this is an important factor in the virulence of bacteria (see Section VI,1). 

The biological activity of acid mucopolysaccharides is discussed in Section 9. They are instrumental in hemagglutination inhibition of viruses, in enhancing virulence of bacteria (S25-S27), and in antilipemic (Cl, C2, P4) and lipotropic activity (C4). They were also reported to have strong antipeptic activity (K21, K24) which we (unpublished) found, however, to be rather low. 

Slower hydrolysis rate by sialidases when compared with NeuSAc, thus possibly hindering spreading and virulence of bacteria [5,33,245]... 

An important virulence factor of bacteria is their ability to adhere to urinary epithelial cells by fimbriae, resulting in colonization of the urinary tract, bladder infections, and pyelonephritis. Other virulence factors include hemolysin, a cytotoxic protein produced by bacteria that lyses a wide range of cells... 

Successful inhibition of virulence in bacteria might have the potential to eliminate antibiotic resistance - by eliminating the antibiotic. In effect, an antivirulence agent would hinder bacteria in their ability to actively infect the human host, but might otherwise leave them intact, and harmless [89,90]. 

The Gram-positive bacterium Streptococcus pneumoniae is an important cause of respiratory tract infections, bacteremia, and meningitis. In this strain, the cell wall anchored pneumococcal surface protein A (PspA) has been demonstrated to bind lactoferrin [181]. PspA and closely related proteins in a variety of pneumococcal isolates are most likely involved in the sequestration of iron from lactoferrins, and finally contribute to the virulence of these bacteria. However, the means by which the pneumococcus acquires iron at the mucosal surface during invasive infection is not well understood at the molecular level [182],... 

Dependence of survival from typhoid on the constitution of the host and the virulence of the bacteria (Gowen). 

Vanderburgh effect the acceleration of puberty in immature females by males. Virulence factor a protein responsible for the ability of bacteria to cause disease. 

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