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Virtual human population

Modeling and Simulation ofADME in Virtual Human Population 1433... [Pg.433]

The purpose of building a virtual human population is to capture all the complex interplay between different sources of variability mentioned above in the form of a network of system information that interacts with drug characteristics measured using in vitro studies and indicates potential co-variations determining the drug therapy outcome (for an example, see Fig. 16.4). [Pg.433]

The results of a study on (.S )-warfarin [38], using virtual human populations, indicated that only 20% of cases (19 of 95 comparisons within 11 PD and 4 PK-PD studies) could show statistically significant differences between wild-type and other individual genotypes (Table 16.1). This was very similar to the percentage observed in reported experimental studies (21%, Chi-squared test, P = 0.80). [Pg.443]

Building Virtual Human Populations Assessing the Propagation of Genetic Variability in Drug Metabolism to Pharmacokinetics and Pharmacodynamics 425... [Pg.526]

McNally K, Cotton R, Hogg A, Loizou G. PopGen a virtual human population generator. Toxicology, doi 10.1016/j. tox.2013.07.009. [Epub ahead of print] PubMed PMID 23876857... [Pg.569]

See other pages where Virtual human population is mentioned: [Pg.425]    [Pg.426]    [Pg.428]    [Pg.430]    [Pg.432]    [Pg.433]    [Pg.434]    [Pg.436]    [Pg.438]    [Pg.438]    [Pg.439]    [Pg.439]    [Pg.440]    [Pg.441]    [Pg.442]    [Pg.443]    [Pg.444]    [Pg.446]    [Pg.526]    [Pg.526]    [Pg.456]    [Pg.591]   
See also in sourсe #XX -- [ Pg.433 , Pg.438 , Pg.443 ]



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