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Viral CKBPs

The mechanism of action of the 35-kDa CKBP is competitive inhibition of CC-chemokine binding to cellular receptors, inhibiting as a consequence the induction of transient increases in calcium concentrations and the migration of cells aloi chemotactic gtadients. - The M-Tl protein of MYXV has the unique ability to interact with GAGs via a GAG bindii domain at its C-terminus that is not present in other 35-kDa fiunily members. This unique property of M-Tl would retain the protein in the vicinity of infected cells and may enhance its abUity to protect the sites of infection from chemoldne-mediated anti-viral responses. [Pg.170]

The A41 and 35-kDa CKBPs from poxviruses arc structurally related but block the chemokine system in different but complementary ways, probably being advantageous for the virus to control the host and-viral responses. [Pg.171]

See other pages where Viral CKBPs is mentioned: [Pg.21]    [Pg.174]    [Pg.361]    [Pg.361]    [Pg.363]    [Pg.365]    [Pg.21]    [Pg.174]    [Pg.361]    [Pg.361]    [Pg.363]    [Pg.365]    [Pg.19]    [Pg.22]    [Pg.22]    [Pg.168]    [Pg.174]    [Pg.359]   
See also in sourсe #XX -- [ Pg.361 , Pg.364 , Pg.365 ]



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Viral CKBPs (vCKBPs)

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