Vigabatrin adverse reaction

The time course of this adverse reaction is typically late. In one case there was rapid loss of visual field after 10 years of apparently well-tolerated treatment with vigabatrin [365 ]. 

Vigabatrin has been studied in an open 1-year extension of a randomized, double-blind, placebo-controlled Canadian trial in 97 adults with resistant partial epilepsy (2). There was a mean weight gain of 3.7 kg by the end of the study. Treatment was discontinued in 12% because of adverse effects. Neurological/psychiatric adverse effects were the most common reason for withdrawal, including three behavioral reactions attributed to the drug. 

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