Vesicle morphology

Uzun O, Sanyal A, Nakade H, Thibault RJ, Rotello VM. Recognition-induced transformation of microspheres into vesicles morphology and size control. J Am Chem Soc 2004 126 14773-14777. 

Unilamellar vesicles prepared from mixtures of cetyl trimethylammonium tosylate and sodium dodecyl benzene sulfonate 8-Al203 prepared in vesicles Morphologies and sizes of 8-Al203 formed in vesicles were investigated by TEM and X-ray diffraction measurements use of vesicles as nanoreactors for the precipitation of ceramic particles was examined 129... 

Synaptic vesicle morphology and organization into functional pools... 

W. R. Burack, a. R. Dibble, M.M. Aliet-TA, and R.L. Biltonen. Changes in vesicle morphology induced by lateral phase separation modulate phospholipase A2 activity. Biophys. J., 1997, 36, 10551-10557. 

Block copolymer systems can form vesicles of a wide range of sizes varying from a few nanometers to a few micrometers. Those in the range of 100-1,OOOnm have been explored extensively. Various types of vesicle morphologies are represented in Fig. 3. 

One of the exceptionally useful aspects of this group s work is not only the wide variety of monomers and polymerization conditions attempted but also the wide variety of characterization methods employed. Like Kaler et al., this group has characterized the initial surfactant vesicle template, the monomer-swollen vesicles, and the final polymeric product. Particular attention was paid to the effect of monomer and polymer on the surfactant bilayer properties. Cryo TEM experiments revealed subtle changes in the vesicle morphology, which were investigated further with micro DSC experiments [21]. 

Vesicle Morphology. An important characteristic of the lamellar surfactant systems is the water layer thickness. The SANS experiments found that the hydrocarbon layer thickness was 3.3 nm and the water layers had a distribution of thicknesses between 30 and 40 nm for the 1/2 (w/w) SDS/C12OH (3 wt. %) sample. 

The addition of water soluble polymers had a significant effect on the vesicle morphology depending on polymer type, molecular weight, and temperature of addition. The results are summarized in Table I. When the polymers were added... 

Table I. Effect of Water Soluble Polymers on Vesicle Morphology...

Figure 23 Cryo-TEM images showing the stages in the peptide-vesicle interaction process from Kros et al. (a) The addition of peptide to CD Vs at physiological pH does not affect vesicle morphology (b) FibCTs are seen 1 h after acidifying the solution (c) The disappearance of fibers is observed when the pH is retnmed to physiological pH. (Scale bar in all images = 100 nm.) (Reproduced from Ref. 83. American Chemical Society, 2009.)...

Hu ZJ, Jonas AM, Varshney SK, Gohy JF (2005) Dilution-induced spheres-to-vesicles morphological transition in micelles from block copolymer/surfactant complexes. J Am Chem Soc 127 6526-6527. doi 10.1021/ja050053m... 

The above morphological changes induced by SMase are clearly distinct from the previously reported effects of another lipolytic enzyme, phospholipase A2. In brief, subjecting l-paImitoyl-2-oleoyl-phosphatidylcholine (POPC) giant liposomes to either external or internal action of PLA2 causes these vesicles to burst and shrink, respectively [43]. These authors also showed that vesicle morphology is not altered by lysozyme, protein having no enzymatic activity towards the bilayer. 

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