Versus Noncompetitive Antagonists

Pharmacologic antagonists are generally divided into two categories depending on whether they are com- 

In contrast to competitive antagonists, noncompetitive antagonists form strong, essentially permanent, bonds to the receptor. Noncompetitive antagonists either have an extremely high affinity for the receptor or actually form irreversible covalent bonds to the receptor.2 45 Once bound to the receptor, the noncom- 

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Hanania, T. and Zahniser, N.R., Locomotor activity induced by noncompetitive NMDA receptor antagonists versus dopamine transporter inhibitors opposite strain differences in inbred long-sleep and short-sleep mice, Alcohol Clin. Exp. Res., 26, 431, 2002. 

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