Verloop

A Verloop, W Hoogenstraaten, J Tipker. In EJ Ariens, ed. Drug Design, Vol VII. New York Academic Press, 1976, p 165. 

Taft sterlc parameter Verloop sterlmol constants ... 

In this chapter, an attempt has been made to present a total number of 20 QSAR models (12 QSAR models for topo I inhibitors and eight QSAR models for topo II inhibitors) on 11 different heterocyclic compound series (an-thrapyrazoles, benzimidazoles, benzonaphthofurandiones, camptothecins, desoxypodophyllotoxins, isoaurostatins, naphthyridinones, phenanthridines, quinolines, quinolones, and terpenes) as well as on some miscellaneous heterocyclic compounds for their inhibition against topo I and II. They have been found to be well-correlated with a number of physicochemical and structural parameters. The conclusion, from the analysis of these 20 QSAR, has been drawn that the inhibition of topo I is largely dependent on the hydrophobicity of the compounds/substituents. On the other hand, steric parameters (molar refractivity, molar volume, and Verloop s sterimol parameters) are important for topo II inhibition. 

Verloop A (1987) The sterimol approach to drug design. Marcel Dekker, New York... 

A. Verloop, The STERIMOL Approach to Drug Design. Marcel Dekker, New York, 1987. L.B. Kier and L.H. Hall, Molecular Connectivity in Structure-Activity Analysis. Wiley, New York, 1986. 

Diflubenzuron (Dimilin , TH-6040) is an IGR which inhibits the normal deposition of chitin. The metabolic fate of diflubenzuron has been studied in sheep U, 2), cattle (1 ), rats (1, 3), house flies (4, 5), stable flies (5), chickens (6), swine (6), boll weevils (7), plants (8 9), and soil (2, 8, 10). Since good reviews of diflubenzuron metabolism have been given by Ivie (11) and Verloop and Ferrell (9), we will present only a tabular summary of the degradation of diflubenzuron in nonaguatic systems for comparative purposes (Table I). The remaining discussion will focus on diflubenzuron degradation in the aquatic environment. 

J. L. Fauchere, M. Charton, L. B. Kier, A. Verloop, V. Pliska, Amino Acid Side Chain Parameters for Correlation Studies in Biology and Pharmacology , hit. J. Pept. Protein Res. 1988, 32, 269 - 278. 

MR, the molar refractivity, which parameterizes polarizability and steric effects and Verloop s parameters, which are steric substituent values calculated from bond angles and distances. 

TIPKER VERLOOP STERIMOL MTD Steric Parameters in QSAR 281... 

Verloop, A. Tipker, J., in "Biological Activity and Chemical Structure" Keverling Buisman, J. A., Ed. Elsevier ... 

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