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VEGF signaling

Fig. 5. Rat epiphysial growth rate (on-treatment). BMS-275291 treatment of young rats induction of epiphysial growth plate expansion and suppressed blood vessel invasion in the femur of a rat given oral BMS-275291, 4000 mg/kg/d for 1 mo. This pharmacologic phenotype resembles reported phenotypes for mice with homozygous MMP-9 deletion as well as mice treated with inhibitors of VEGF signaling. Fig. 5. Rat epiphysial growth rate (on-treatment). BMS-275291 treatment of young rats induction of epiphysial growth plate expansion and suppressed blood vessel invasion in the femur of a rat given oral BMS-275291, 4000 mg/kg/d for 1 mo. This pharmacologic phenotype resembles reported phenotypes for mice with homozygous MMP-9 deletion as well as mice treated with inhibitors of VEGF signaling.
VEGF Signaling A Therapeutic Target for Cardiovascular Disease... [Pg.301]

This review focuses on recent evidence supporting the concept that VEGF signaling pathways are suitable targets for modulating angiogenesis linked to various cardiovascular diseases. [Pg.301]

VEGF overexpression also produces similar results. The mutant embryos display several developmental anomalies consisting of an attenuated compact layer of myocardium, overproduction of trabeculae, defective ventricular septation, aberrant coronary development due to oversized epicardial vessels, and also abnormalities in outflow track remodeling (Miquerol et al. 2000). These findings suggest that VEGF signaling is critical for cardiovascular development. [Pg.310]

Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J... [Pg.550]

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