Vasopressin receptor agonists

Many hundred analogues have been synthesized, and some more active as vasopressin receptor agonists than the parent are listed here desamino[Dab ]vasopressin hydroxy-[Val , DArg ] vasopressin desamino[Thr, DArg ] vasopressin desamino [Asn. DArg ) vasopressin hydroxy-[pArg ] vasopressin deamino(Val, DHomoarginyl ]-... 

DIABETES INSIPIDUS TREATMENT involves the administration of drugs to counteract the under-production of antidiuretic hormone (ADH vasopressin) by the pituitary gland, which is a characteristic of diabetes insipidus. ADH itself (arginine vasopressin or lysine vasopressin) can be used, as can the analogues desmopressin and terlipressin. These are all (V subtype) VASOPRESSIN RECEPTOR AGONISTS. These agents are discussed... 

BMY 40900 Videx ) is a synthetic reverse transcriptase INHIBITOR, active as an ANTIVIRAL and used in anti-hiv treatment. It is mainly administered to patients who are intolerant to. or have not benefited from, zidovudine, didehydroproline oxytocin ((t -Pro joxytocin) is an analogue of oxytocin and an agonist at oxytocin receptors (i.e. an (OT) VASOPRESSIN RECEPTOR AGONIST) with greater OXYTOCIC activity than oxytocin. 

Tht Gly JoxytOCin is a synthetic analogue of oxytodn and agonist at oxytocin receptors (i.e. an (OT) VASOPRESSIN RECEPTOR agonist) that has 07CYT0CIC activity and is more potent than oxytocin. 

AVP), except in the pig which has a Lys residue (iysine vasopressin). Oxytocin differs from vasopressin in having leucine at position 8 and isoleucine at position 3. Vasopressin and oxytocin analogues with some degree of receptor subtype selectivity that have been synthesized have ANTIDIURETIC or vasoconstrictor or OXYTOCIC (uterine-contracting) activity. See VASOPRESSIN RECEPTOR AGONISTS VASOPRESSIN RECEPTOR ANTAGONISTS. 

---