Oxytocin and analogues

Hundreds of analogues of both oxytocin and vasopressin have been synthesized, and the conformations of many of these have been studied (22,23). 

Table 4. Synthetic Analogues of Oxytocin and Vasopressin Having Antagonist Activities...

Fortunately, nature has provided a very useful cysteine derivative, D-penicillamine ( 3, 3-dimethylcysteine), which is readily available and inexpensive (the L-isomer is also available, but is much more expensive). The usefulness of this amino acid in biologically active peptide analogues was shown by Schulz and du Vigneaud1 141 who incorporated it into oxytocin and... 

D. P. Lundin, S. Lundin, H. Olson, B, W. Karisson, B. R. Weatrom, and S. O. Pierzynowski. Enhanced intestinal absorption of oxytocin peptide analogues in the absence of pancreatic juice in pigs Pham, Res. 72 1478-1482(1995). 

Hormones and analogues growth hormone corticotrophin (ACTH) calcitonin desmopressin (DD AVP) lypressin oxytocin buserelin nafarelin progesterone norethisterone 17/1-estradiol testosterone insulin Gonadorelin (Gonadotrophin-releasing hormone GnRH LH-RH)... 

BMY 40900 Videx ) is a synthetic reverse transcriptase INHIBITOR, active as an ANTIVIRAL and used in anti-hiv treatment. It is mainly administered to patients who are intolerant to. or have not benefited from, zidovudine, didehydroproline oxytocin ((t -Pro joxytocin) is an analogue of oxytocin and an agonist at oxytocin receptors (i.e. an (OT) VASOPRESSIN RECEPTOR AGONIST) with greater OXYTOCIC activity than oxytocin. 

Wold, S., Eriksson, L., Hellberg, S Jonsson, J., Sjostrom, M., Skagerberg, B. and Wikstrdm, C. (1987) Principal property values for six non-coded amino acids and their application to a structure-activity relationship for oxytocin peptide analogues. Can.]. Chem., 65, 1814-1820. 

Polachek I, Krejci I, Rudinger J. 1967. The action of oxytocin and synthetic analogues on the isolated mammary-gland myoepithelium of the lactating rat Effect of some ions. J Endocrinol 38 13-24. 

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