Vascular diseases oxide reactions

F15. Freeman, B. A., White, C. R., Gutierrez, H., Paler-Martinez, A., Tarpey, M. M., and Rubbo, H., Oxytgen radical-nitric oxide reactions in vascular diseases. Adv. Pharmacol. 34,45-69 (1995). 

Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases... 

The disturbance of balance between superoxide and nitric oxide occurs in a variety of common disease states. For example, altered endothelium-dependent vascular relaxation due to a decrease in NO formation has been shown in animal models of hypertension, diabetes, cigarette smoking, and heart failure [21]. Miller et al. [22] suggested that a chronic animal model atherosclerosis closely resembles the severity of atherosclerosis in patients. On the whole, the results obtained in humans, for example, in hypertensive patients [23] correspond well to animal experiments. It is important that endothelium-dependent vascular relaxation in patients may be improved by ascorbic acid probably through the reaction with superoxide. 

Michotte has suggested that biolt ical oxidation processes in mesenchymal tissues require a balance of C -hydroxysteroids and adrenergic substances, and this is disturbed in rheumatic diseases owing to the failure of the adrenergic component. It is alleged that pyrocatechoic acid (V) may replace this component, restore the physiological imbalance and, consequently, suppress the inflammatory reaction. Adams and Cobb found that neither pyrocatechoic acid nor its diacetyl derivative administered orally inhibits ultra-violet erythema in the guinea-pig. The former compound, administered subcutaneously, reduces vascular permeability in the mouse peritoneum, but the effect is less than that of salicylic acid . Other dihydroxybenzoic acids tested are not active in this system . 

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