Vanillin amycolatopsis

Vanillin Ferulic acid Amycolatopsis, Streptomyces Up to 18 g L" , 50 h, l-lOtyear In situ product recovery by crystallisation at more than 10 g L possible [8, 90, 91]... 

Givaudan developed a strain of Streptomyces, which produces vanillin from ferulic acid. Pseudomonas strains possess this ability too, and fermentation with Amycolatopsis leads similarly to vaniUin. The most important producers of vaniUin from ferulic acid are Symrise and Rhodia (Rhovanil Natural- [152]... 

An example of this approach was outlined by Gatfield [65] on the conversion of ferulic acid to vanillin (Figure 9.12). Ferulic is an abundant, inexpensive, natural vanillin precursor recovered from waste streams or from the fermentation of eugenol [87]. While many miCTobial systems have been found that accomplish the desired bioconversion, Gatfield [65] has suggested that Amycolatopsis species is the most efficient providing vanillin concentrations up to lOg/L in a fermentation period of only 36 h [88,89]. This is an excellent yield and few side products were found. 

Several microorganisms have been discovered and/or engineered that are able to produce vanillin in high yields from ferulic acid. The most important strains for this purpose are ceitz n y Amycolatopsis sp. in particular, ATCC 39116 (formerly known as Streptomyces setonii) afforded a yield of 13.9 gl" [45,46]. 

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