VandeWalle approach

Visser-Vandewalle V et al Chronic bilateral thalamic stimulation A new therapeutic approach in intractable Tourette syndrome. Report of three cases. J Neurosurg 2003 99 1094. [PMID 14705742]... 

A practical approach to unnatural (+)-shikimic acid derivative 197 (Scheme 32) was proposed by Vandewalle, based on extensive transformation of the desymmetrized building-block 193 [47], The... 

The great advantage of the type of approach used by Vandewalle is that a variety of stereochemistries of different substituents around a bicyclo[2.2. l]hep-tane skeleton is accessible using different Diels-Alder reactions, making a stereospecific approach to many iridoids possible by relatively simple manipulations of the functional groups. 

A similar strategy has been employed by Vandewalle et al. in the total synthesis of verbenalin aglycone ( ref 17 ), but a different approach has been used for the stereoselective synthesis of the bicyclooctene key synthon. 

Considerable progress in that approach, namely in formulating rules for structural design of elements, was achieved by the work of the RILEM Technical Committee 162-TDF Test and design methods for steel fibre reinforced concrete led by L. Vandewalle (2000) and Vandewalle et al. (2003). The input from the fibres is based on the evaluation of the area under the respective portions of the load-deflection curves, related to the selected limit states. Section 10.2.4. 

The reliable formulae and extensive test results for polymer and fibre-reinforced composites are scarce. Simple relations for the prediction for shrinkage and creep of ordinary concretes for application in structural design were given already in CEB-FIP Model Code (1990) with coefficients to allow for actual conditions. Later, so-called Model B3 was recommended by ACI (1999) and extensively discussed by Bazant and Baweja (1995). A sHghtly different approach was proposed in EN 1992 (2004) and detailed comments may be found in Vandewalle (2000). 

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