Vancomycin model studies

D. Vancomycin model studies Closing Remarks Acknowledgments References... 

MP Gasper, A Berthod, UB Nair, DW Armstrong. Comparison and modeling study of vancomycin, ristocetin A, and teicoplanin for CE enantioseparations. Anal Chem 68 2501-2514, 1996. 

Draw these atropisomers and show that only one can be converted to vancomycin. The synthesis of the aglycon was completed by functional manipulation and addition of ring E by chemistry similar to that detailed earlier. Yet, another set of atropisomers (this time of ring E) was formed However, this one was more easily equilibrated than the others model studies had shown that the activation barrier for this set of atropisomers should be lower than that of the others. 

The recommended therapy for patients with left-sided IE caused by methicillin-sensitive S. aureus (MSSA) is 4 to 6 weeks of naf-cUlin or oxacillin, often combined with a short course of gentamicin (see Table 109-6). Erom in vitro studies, the combination of an aminoglycoside and peniciUinase-resistant penicillin or vancomycin enhances the activity of these drugs toward MSSA. In animal models of endocarditis, combinations of penicillin with an aminoglycoside eradicate organisms from vegetations more rapidly than penicillins... 

Recently, the detechon of vancomycin resistant enterococci (VRE) using MALDI-TOF MS profiles and a support vector machine has been described [74]. Internal cross-vahdation of the optimal statishcal model resulted in a sensitivity of 92.4% and a specificity of 85.2%. A subsequent external validation study after incorporation of the algorithm into the rouhne laboratory workflow surprisingly showed an even higher sensihvity and specificity of 96.7% and 98.1%, respectively. A further advantage was the rehable differentiation from other, intrinsically vancomycin resistant species. These excellent results did lead to incorporation of the analysis into the authors rouhne laboratory workflow. The broad applicability of the method shU has to be shown. 

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