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Valproate/valproic acid hepatotoxicity

Levy RH, Rettenmeier AW, Anderson GD, Wilensky AJ, Friel PN, Baillie TA, Acheampong A, Tor J, Guyot M, Loiseau P. Effects of poly therapy with phenytoin, carbama-zepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid. Qin Pharmacol Ther 1990 48(3) 225-35. [Pg.2820]

A. Severe valproate-induced hepatotoxicity, hyperammonemia, coma, or acute valproic acid overdose. Early intervention with iV (rather than orai)... [Pg.426]

Efavirenz levels were not altered by valproic acid in one study in mV-positive patients, and valproic acid levels were not different to those in a control group not taking efavirenz. However, one patient had a marked decrease in valproate levels after starting efavirenz. A case of hepatotoxicity has occurred in a patient taking valproic acid with nevirapine and saquinavir/ritonavir. [Pg.782]

A case of valproate-associated hepatotoxicity occurred in a 51-year-old man about 3 weeks after he started nevirapine 200 mg twice daily, saquinavir/ritonavir 400/400 mg twice daily, and stavudine. Serum valproic acid levels remained therapeutic. ... [Pg.782]

See other pages where Valproate/valproic acid hepatotoxicity is mentioned: [Pg.380]    [Pg.213]    [Pg.1115]    [Pg.343]   
See also in sourсe #XX -- [ Pg.714 , Pg.715 , Pg.1044 , Pg.1115 ]



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Hepatotoxity

Valproate

Valproate/valproic acid

Valproic acid

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