Valdez-Rojas

Reichardt (2003, p. 504) presents a table of solvents recommended as replacements for more hazardous ones. Total avoidance of solvent is sometimes a possibility. An example was mentioned in Chapter 1. Scott (2003) discusses the scope of solvent-free methods and considerations of mutual solubility of reactants and of control, including exothermic reactions. A recent application is the solvent-free synthesis by Valdez-Rojas et al. (2012) of thioamides and alpha-ketothioamides through the Willgerodt-Kindler reaction. Scheme B. 

Valdez-Rojas JE, Rios-Guerra H, Ramirez-Sanchez AL, Garcia-Gonzalez G, Alvarez-Toledano C, L6pez-Cortes JG, Toscano RA, Penieres-Carrillo JG. Can J Chem 2012 90(7) 567-573. 

Diaz-Rojas, E.I., Pacheco-Aguilar, R., Lizardi, J., Arguelles-Monal, W., Valdez, M.A., Rinaudo, M., and Goycoolea, F.M. 2004. Linseed pectin Gelling properties and performance as an encapsulation matrix for shark liver oil. Food Hydrocolloids 18, 293-304. 

A. Valdez-Calderon, J. M. Torres-Valencia, J. J. Manriquez-Torres, R. Velazquez-Jimenez, M. A. Gomez-Hurtado, L. U. Roman-Marin, J. D. Hernandez-Hernandez, C. M. Cerda-Garcias-Rojas and P. Joseph-Natan, Nat. Prod. Commun., 2011, 6, 1225. 

---

See also in sourсe #XX -- [ ]

---