V-Methylpiperidine

V-methylpiperidine oxide [17206-00-7] does not undergo the reaction because of its inabihty to achieve the highly strained transition configuration, whereas the... 

AF-DX 116, ll-( 2-[(diethylamino)methyl]-l-piperidinyl acetyl)-5,ll-dihydro-6H-pyrido-[2,3-b](l,4)benzodiazepine-6-one DAG, diacylglycerol IP3, inositol trisphosphate 4-DAMP, 4-diphenylacetoxy-/V-methylpiperidine. 

The same /V-methylpiperidine derivative was obtained by sodium-ammonia degradation of O-acetyllagerine methiodide. It was difficult, however, to distinguish the NMR spectra of 61 from an isomer with 4-alkylpyrocatechol structure. This possibility could not be excluded by analysis of UV spectrum of the A -oxide of 61. 

A. Vincze, L. Gefen, A. Fisher and P. Bel, Low resolution electron impact mass spectra of some quinuclidine and /V-methylpiperidine glycolates, J. Forens. Sci., 25(3), 655-665 (1980). 

The lH and 13C NMR spectra also indicate an NC//j group (bc/SH = 39.612.92) and an OCH3 group (5cISH = 53.413.66). The CH connectivities D of the NCH3 protons (SH = 2.92) across three bonds to the C atoms at 5C = 65.3 and 64.5, derived from the CH COLOC plot, are especially informative, because the combination of C and D gives the /V-methylpiperidine residue E with four spare bonds ... 

Another common fragment in medicinal chemistry is V-methylpiperidine [43]. Fig. 6 shows the calculated energy difference between the axial and equatorial con-formers for the different force fields. All force fields correctly predict the equatorial... 

This plant yielded V-methylpiperidine and girgensonine, C13H16ON2 (m.p. 144-146 or 147-148°, [a] 0° picrolonate, m.p. 192-194°), which proved to be iV-piperidyl-p-hydroxyphenylacetonitrile. Hydrolysis with alcoholic potash generated piperidine, hydrogen cyanide, and p-hydroxy-benzaldehyde. Its synthesis was accomplished by a recombination of these fragments (67). 

Piperidine or lithium piperidide and benzyne form N-phenylpiperidine, as expected, but the same product (40-50%) was also obtained unexpectedly from V-methylpiperidine, fluorobenzene, and phenyllithium before the formation of benzyne under these conditions was properly recognized. A series of N-alkylmorpholines gives secondary and tertiary aniline derivatives 213 and 214 when treated with bromobenzene and sodium amide. A route for formation of these products via the ylid 211 is outlined in Scheme 19, in which the formation of 211 is similar to that of 16 in Scheme 2 and the step 212 -+ 213 is similar to the decomposition of 33 in Scheme 5. The final... 

V-Methylpiperidine no hydrt en bonding possible to other iV-methylpiperidine molecules... 

Li X, Zeng Z, Garg S, Twamley B, Shreeve JM (2008) Fluorine-containing ionic liquids from V-alkylpyrrolidine and V-methylpiperidine and fluorinated acetylacetones low melting points and low viscosities. Eur J Inorg Chem 3353-3358... 

Activation of Carboxylic Acids as Mixed Anhydrides. Activation of A-(alkoxycarbonyl)-a-amino acids as mixed anhydrides using MCF/(V-methylpiperidine in CH2CI2 minimizes urethane byproduct formation and racemization during peptide bond formation. Reaction of these mixed anhydrides with N,0-Dimethylhydroxylamine followed by LiAlHq reduction provides an attractive route to the corresponding (V-(alkoxycarbonyl)-a-amino aldehydes (eq 13). Attempts to generate mixed anhydrides from iV-acyl-oe-amino... 

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