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V-acetyllactosamine

Glycan array allows for the definition of fine differences in specificity among related lectins giving clues about the basis for differences in their biological activities. For example comparison of a set of human galectins demonstrated that Gal-1, Gal-2, and Gal-3 all bind /V-acetyllactosamine but... [Pg.357]

EC 2.4.1.90 /V-Acetyllactosamine synthase UDP-galactose + iV-acetyl-D-glucosamine UDP Af-acetyllactosamine Golgi apparatus ... [Pg.253]

Synthesis of Derivatives of V-acetyllactosamine from Lactal Hexa-acetate. Hexa-0-acetyl-2-deoxy-2-phthalimido-/l-D-lactosyl Chloride, R. U. Lemieux, S. Z. Abbas, H. M. Burzynska, and R. M. Ratcliffe, Can. J. Chem., 60 (1982) 63-67. [Pg.25]

Fig. 9. Synthesis of /V-acetyllactosamin (LacNAc, 7) with pl-4 galactosidase. The thermodynamic approach (reverse hydrolysis) involves D-galactose (5) as donor and /V-acctyl-D-glucosanminc (6) as acceptor substrate. Activated galactosyl donors (8-10) are used in the kinetic approach (trans-glycosylation)... Fig. 9. Synthesis of /V-acetyllactosamin (LacNAc, 7) with pl-4 galactosidase. The thermodynamic approach (reverse hydrolysis) involves D-galactose (5) as donor and /V-acctyl-D-glucosanminc (6) as acceptor substrate. Activated galactosyl donors (8-10) are used in the kinetic approach (trans-glycosylation)...
H Chemical Shifts of Structural-reporter Groups of Constituent Monosaccharides for Glycopeptides of the. V-Acetyllactosamine Type... [Pg.314]

Mong TK-K, Huang C-Y, Wong C-H. A new reactivity-based one-pot synthesis of V-acetyllactosamine oligomers. J. Org. [Pg.626]

Ujita M, Fukuda M. Regulation of poly-V-acetyllactosamine biosynthesis in O-glycans. Trends Glycosci. Glycotech. 2001 13(70) 177-191. [Pg.646]

Sasaki K, Kurata-Miura K, Ujita M, Angata K, Nakagawa S, Sekine S, Nishi T, Fukuda M. Expression cloning of cDNA encoding a human P-l,3-Ai-acetylglucosaminyltransferase that is essential for poly-V-acetyllactosamine synthesis. Proc. Natl. Acad. Sci. U.S.A. 1997 94(26) 14294-14299. [Pg.649]

Zhou DP, Dinter A, Gallego RG, Kamerhng JP, Vliegenthart JFG, Berger EG, Hennet T. A f -l,3-Ai-acetylglucosaminyltrans-ferase with poly-V-acetyllactosamine synthase activity is sfiuc-turally related to P-l,3-galactosyltransferases. Proc. Natl. Acad. Sci. U.S.A. 1999 96(2) 406-411. [Pg.649]

Torii T, Fukuta M, Habuchi O. Sulfation of sialyl V-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. Glycobiology 2000 10(2) 203-211. [Pg.649]

This polysaccharide is structurally a poly-(/V-acetyllactosamine) chain, as seen... [Pg.288]

The structure of some of these oligosaccharides has been determined. A major N-glycan representing about 45% of the carbohydrate chains is a monosialylated monofucosylated diantennary glycan of the V-acetyllactosaminic type (Fig. 12A)[81]. A tetraantennary glycan of the V-acetyllactosaminic type has also been isolated and its structure determined by methylation analysis and 500MHz H-NMR (Fig. 12B)[82]. The major O-glycan of human vWf was shown to be a diantennary tetrasaccharide (Fig. 12C)[83]. [Pg.191]

Fig. 11.1-2 (a) Structure of S-type lectin, galectin-3, bound to /V-acetyllactosamine and... [Pg.642]

Several fucosyltransferases have been isolated and used for in vitro synthesis. The Lewis A al,4-fucosyltransferase transfers unnatural fucose derivatives in from their GDP esters [23]. The enzyme al,3-fucosyltransferase has been used to L-fucosylate the 3-posi-tion of the GlcNAc of iV-acetyllactosamine and of sialyl a2,3-/V-acetyllactosamine [24]. Several acceptor substrates with modifications in the GlcNAc residue could also be... [Pg.252]

Additional precursors in the use of the above strategy were prepared under two concise synthetic routes as outlined in Scheme 14. In the first approach, p-nitrophenyl thiolactoside 19 and /V-acetyllactosamine derivative 63 were used as starting... [Pg.83]


See other pages where V-acetyllactosamine is mentioned: [Pg.12]    [Pg.227]    [Pg.313]    [Pg.49]    [Pg.78]    [Pg.94]    [Pg.264]    [Pg.412]    [Pg.1370]    [Pg.298]    [Pg.304]    [Pg.306]    [Pg.310]    [Pg.544]    [Pg.175]    [Pg.319]    [Pg.581]    [Pg.162]    [Pg.130]    [Pg.130]    [Pg.217]    [Pg.337]    [Pg.337]    [Pg.343]    [Pg.97]    [Pg.135]    [Pg.199]    [Pg.250]    [Pg.690]    [Pg.1266]    [Pg.1302]   
See also in sourсe #XX -- [ Pg.11 , Pg.265 , Pg.717 ]




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Of /V-acetyllactosamine

Poly-V-acetyllactosamine

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