V-acetyllactosamine

EC 2.4.1.90 /V-Acetyllactosamine synthase UDP-galactose + iV-acetyl-D-glucosamine UDP Af-acetyllactosamine Golgi apparatus  

Synthesis of Derivatives of V-acetyllactosamine from Lactal Hexa-acetate. Hexa-0-acetyl-2-deoxy-2-phthalimido-/l-D-lactosyl Chloride, R. U. Lemieux, S. Z. Abbas, H. M. Burzynska, and R. M. Ratcliffe, Can. J. Chem., 60 (1982) 63-67. 

Ujita M, Fukuda M. Regulation of poly-V-acetyllactosamine biosynthesis in O-glycans. Trends Glycosci. Glycotech. 2001 13(70) 177-191. 

This polysaccharide is structurally a poly-(/V-acetyllactosamine) chain, as seen 

Torii T, Fukuta M, Habuchi O. Sulfation of sialyl V-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. Glycobiology 2000 10(2) 203-211. 

Mong TK-K, Huang C-Y, Wong C-H. A new reactivity-based one-pot synthesis of V-acetyllactosamine oligomers. J. Org. 

Fig. 11.1-2 (a) Structure of S-type lectin, galectin-3, bound to /V-acetyllactosamine and 

H Chemical Shifts of Structural-reporter Groups of Constituent Monosaccharides for Glycopeptides of the. V-Acetyllactosamine Type 

Additional precursors in the use of the above strategy were prepared under two concise synthetic routes as outlined in Scheme 14. In the first approach, p-nitrophenyl thiolactoside 19 and /V-acetyllactosamine derivative 63 were used as starting 

Several fucosyltransferases have been isolated and used for in vitro synthesis. The Lewis A al,4-fucosyltransferase transfers unnatural fucose derivatives in from their GDP esters [23]. The enzyme al,3-fucosyltransferase has been used to L-fucosylate the 3-posi-tion of the GlcNAc of iV-acetyllactosamine and of sialyl a2,3-/V-acetyllactosamine [24]. Several acceptor substrates with modifications in the GlcNAc residue could also be 

Glycan array allows for the definition of fine differences in specificity among related lectins giving clues about the basis for differences in their biological activities. For example comparison of a set of human galectins demonstrated that Gal-1, Gal-2, and Gal-3 all bind /V-acetyllactosamine but 

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