V-acetylgalactosaminyltransferase

Purification of / -1,3-/V-Acetylgalactosaminyltransferase From Haemophilus influenzae Strain Rd... 

Both N-Acetylgalactosaminyltransferase and gal-actosyltransferase activities were suppressed when the cells were pre-treated with opiates or opiate peptides as shown in Table IV. The time course for such studies is obviously crucial and Table V shows an example where the potent opiate fentanyl was used as the inhibitor. It can be seen that the initial inhibition is only observed for 24-48 hrs and that after this time glycosyltransferase levels appear to be normal. 

Imberty A., Piller V., Piller F., and Breton C. Fold recognition and molecular modeling of a lectin-like domain in UDP-GalNac polypeptide N-acetylgalactosaminyltransferases. Protein Eng. 10 1353-1356, 1997. 

TABLE V. A-Acetylgalactosaminyltransferase Activity in Mouse Cells Lytically Infected and Transformed by Polyoma Virus"... 

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