Uterine drug absorption

The IM and SC routes are by far the most frequently used extravascular parenteral routes of drug administration in farm animals. The less frequently used parenteral routes have limited application, in that they aim at directly placing high concentrations of antimicrobial agent close to the site of infection. These routes of administration include intra-articular or subconjuctival injection and intra-mammary or intra-uterine infusion. These local routes differ from the major parenteral routes in that absorption into the systemic circulation is not a prerequisite for delivery of drug to the site of action. The combined use of systemic and local delivery of drug to the site of infection represents the optimum approach to... 

A great many alkaloids have been found to possess uterine stimulating properties. It is unfortunate that so few of them are therapeutically useful drugs. However, those that are clinically important are very effective d ugs and, when employed judiciously, are extremely valuable therapeutic agents. The usefulness of a drug is determined by manj factors, such as, the rate of its absorption and elimination its diffusibility the rapidity and persistence of its action its side effects and therapeutic index. Tftese aspects of its pharmacology can only be studied, of course, in the intact animal, and preferably in the human subject. In this connection, it should be pointed out that the uterine actions of the majority of... 

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