Using Rational Design to Discover New MCRs

Designing new multicomponent approaches in a less haphazard and more rational manner is vital for increasing the limited scaffold diversity obtained by the MCRs reported 

FIGURE 1.2 Fogg s simple classification of one-pot processes involving multiple catalytic transformations. 

FIGURE U Single reactant replacement method for MCRs. 

1 SRR This strategy was first proposed by Ganem [26] and involves the replacement of one reactant with a different reactant that shows the same essential reactivity with other reagents, carrying ont the same role in the reaction mechanism (Fig. 1.3). This approach has been demonstrated to be a valuable tool, providing different final addncts by incorporating additional functionalities in the reactants. 

FIGURE lA Example of a reaction-operator strategy carried out by changing two snbstrates. 

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