Using Lithium-or Magnesium-Lanthanum Mixed-Metal Bases

10 Using Lithium- or Magnesium-Lanthanum Mixed-Metal Bases 

Salt-activated La(TMP)3-3MgCI,-5LiCI can be used to deprotometalate functionalized activated arenes in THF. As previously noted using Zr(TMP) -4MgClj-6LiCl, a stoichiometric amount of base can be employed. Palladium-catalyzed cross-coupling with aryl iodides or direct electrophilic 

TABLE 27.17 Substituted Benzenes Deprotometalation Usii a Lithium—Cadmium Combinatimi and Subsequent lodolysis 

TABLE 27.18 Substituted Benzenes Deprotometalation Using a Lithium-Lanthanum Base and Subsequent Interception with Electrophiles 

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