Used in Gastrointestinal Dysfunction

Mechanism of action PGEj analog, which is cytoprotective mucus and bicarbonate secretion and HQ secretion 

Uses Selective use in NSAID-induced gastrointestinal ulcers 

Antacid Alkalosis Acid Rebound Diarrhea Constipation Other Toxicity 

Mg(OH)2 ++ ++ Hypermagnesemia — loss of deep tendon reflexes, respiratory paralysis 

Opioid analgesics (e.g., morphine) have duality of action i emesis by activating receptors that decrease pain transmission and T emesis by activating receptors in the CTZ. 

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