Ursodeoxycholic acid Ciclosporin

CICLOSPORIN URSODEOXYCHOLIC ACID t cidosporin levels t absorption Watch for early features of cidosporin toxicity monitor FBC closely... [Pg.367]

Ciclosporin + Bile acids or Ursodeoxycholic acid (Ursodiol)... [Pg.1025]

Ursodeoxycholic acid unpredictably increases the absorption and raises the serum levels of ciclosporin in some but not all patients. Bile acids (cholic/dehydrocholic acids) appear not to interact with ciclosporin. [Pg.1025]

When an interaction occurs it is thought to do so because the ursodeoxycholic acid improves micellation of the oil-containing oral ciclosporin formulation so that its absorption is increased. ... [Pg.1026]

Information is limited but bile acids do not apparently interact with ciclosporin, while the interaction with ursodeoxycholic acid appears to be uncertain and unpredictable. It would therefore be prudent to monitor the effects of adding or stopping ursodeoxycholic acid in any patient taking ciclosporin, being alert for the need to adjust the ciclosporin dosage. More study is needed. [Pg.1026]

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