Uronides

The polysaccharides present in the pectin-rich extract ChSS were fractionated, based on their charge density for further characterisation. The elution pattern of ChSS is shown in Figure 1, and it can be seen that the relative uronide content of the fractions increased with increasing salt concentration of the eluens. 

Ahmed, A.E.R. and Labavitch, J.M. 1977. A simplified method for accurate determination of cell wall uronide content. J. Food Biochem. 1 361-365. 

Further illustration of the inadequacy of hypobromite oxidation for the conversion of glycosides to uronides is the work of Jackson and Hudson.79 Only a twelve percent yield of the brucine salt of methyl a-D-mannuronoside was obtained because of oxidative cleavage of the carbon chain of methyl a-D-mannopyranoside. 

SOAP = soluble organic anions and polyanions (e.g., low FW carboxylates such as acetate, uronides, and phenolates as well as high FW fulvates and humates). 

The Pseudomonas enzyme diflFered from the Erwinia enzyme in that saturated oligogalacturonides were degraded as rapidly as the corresponding unsaturated uronides activity was maximal with tetramers, follower by trimer, dimer, and then polymer and Ca stimulated activity. With a purified enzyme preparation the reaction product from unsaturated digalacturonic acid was 4-deoxy-5-keto-D-glucuronic acid with crude extract a mixture of this acid and 4-deoxy-5-keto-D-fructuronic acid resulted. 

Dl. Danishefsky, I., Eiber, H. B., and Langholtz, E., Investigations on the chemistry of heparin II. Presence of a uronidic linkage with carbon-6 of glucosamine. Biochem. Biophys. Res. Commun. 3, 571-574 (1960). 

Studies of the methylation products have also supplied evidence for the identification of these acids. After complete methylation and hydrolysis of the aldobionic or polyuronic acid, it is often possible to isolate the methylated uronide as the lactone, or methyl ester. The acid may also be oxidized to the methylated dibasic acid and identified as such. Furthermore, after methylation and hydrolysis of pectic and... 

Cortisol, a steroid hormone, is reduced and conjugated with gluc-uronide or sulfate and excreted in the urine and the feces. 

Before starting any structural modulation, we first evaluated the effect of the C-9-C-10 unsaturation on antimalarial activity and ascertained that the presence of a CF3 group at C-10 could disfavor the protonation leading to oxonium 14, and hence the further gluc-uronidation (see Scheme 6.4). The antimalarial activities of glycals 10 and 18 have been assessed and compared (see Figure 6.3) [58], Whereas in vitro activities on P. falciparum... 

Urispadol, Urispas, Uronid fluoxetine Adofen, Apo-Fluoxetine, Dom-Fluoxetine, Fluctin,... 

A. Linko, K. Meyer, and P. Hoffman. The production of unsaturated uronides by bacterial hyaluronidases. J. Biol. Chem. 279 13 (1956). 

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