Uric acid glycole

O-methylation at the neighboring carbonyl groups. It is interesting that uric acid glycols (12b, R=H) and uric acid glycol ethers (12b, R = alkyl) are solely JV-methylated here the electronic and steric relationships are different. 

Some mammals have urate oxidase, which metabolizes uric acid to a much more soluble product, allantoin. Administration of the enzyme to humans could be useful in the treatment of gout. This assay was designed to measure the activity of urate oxidase bound to polyethylene glycol. 

Huot, J.-Y., Page, M., Jolicoeur, C., 1991. Thermodynamicproperties of naphthalene and uric acid in ethylene glycol-water mixtures. J. Sol. Chem. 20, 1093-1112. 

CA films by using the phase inversion process. These CA films were cast from solvent/nonsolvent solutions to yield size exclusion membranes consisting of a thin permselective outer layer and a more porous sublayer. These membranes permitted the rapid permeation of a 1500-dalton poly (ethylene glycol) ester of ferrocene however the reproducibility of results presents a problem with these CA mem-branes. Christie et demonstrated that thin films of plasticized polyvinylchloride (PVC), normally used for potentiometric ion-selective electrode applications, applied to electrodes over a polycarbonate dialysis membrane offered improved selectivity ratios for the amperometric detection of phenolic compounds and H2O2 in the presence of the common biological interferents, ascorbic acid and uric acid, over those observed at the dialysis membrane alone or at a composite dialysis/membrane. 

Fig. 5.3 Chromatograms of urinary acidic metabolites extracted using DEAE-Sephadex and separated as their ethoxime and trimethylsilyl derivatives on OV-101 by temperature programming on a packed column (upper) and WCOT capillary column (lower). Selected peaks are identified for comparative purposes. These are 1, lactic 2, glycollic 3, oxalic 4, sulphate 5, phosphate 6, succinic 7, 4-deoxyerythronic 8, 4-deoxythreonic 9,3-deoxytetronic 10,2-deoxytetronic 11, erythronic 12, threonic 13, 3-hydroxy-3-methylglutaric 14, citric 15, uric 16, n-tetracosane (standard) 17, n-hexacosane (standard) (Tracey and Chalmers, unpublished).

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