Urge-to-cough

Whole body 0.5, I, 2.0 4 h At the two lower concentrations, subjects detected odor and reported throat irritation and an urge to cough. At 2 ppm, effects were reported to be more irritating. Anglen 1981... 

Resp 5CP (Urge to cough irritation to nose and throat)... 

But the influence of cough inputs extends far beyond the brainstem. They cause the sensations of irritation and urge-to-cough (see later), and activate many parts of the cerebral cortex and upper brain. This has been well illustrated by the functional magnetic resonance brain imaging studies in humans that associate the urge-to-cough sensation with cortical neuronal activation pathways (Mazzone et al. 

Urge-to-cough is a distinct sensation that, with increasing levels of cough stimulation, has a lower threshold and occurs before the cough itself (Davenport 2008 ... 

Davenport PW (2008) The urge-to-cough A respiratory sensation. In Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough. Handbook of experimental pharmacology, vol 187, Springer, Berlin (in press)... 

Davenport PW, Bolser DC, Vickroy T, Berry RB, Martin AD, Hey JA, Danzig M (2007) The effect of codeine on the Urge-to-Cough response to inhaled capsaicin, Pulm Pharmacol Ther 20 338-346... 

Mazzone SB, McLennan L, McGovern AE, Egan GF, Farrell MJ (2007) Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging, Am J Respir Crit care Med 176 327-332... 

In the last decade there has been a gradual change in opinion on the control of cough as the research focus has moved more towards the study of human cough. Studies on the voluntary control of cough (Lee et al. 2002), placebo effects (Eccles 2006) and the sensation of the urge to cough (Davenport et al. 2007) have... 

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