Urea hydrochloride

Subsequent chlorination of the amide takes place ia a two-phase reaction mixture (a dispersion of diamide ia hydrochloric acid) through which a chlorine stream is passed. The temperature of this step must be maintained below 10°C to retard the formation of the product resulting from the Hofmann degradation of amides. Reaction of the A/,A/-dichloroamide with diethylamine [109-89-7] ia the presence of base yields /n j -l,4-cyclohexane-bis-l,3-diethylurea (35), which is transformed to the urea hydrochloride and pyroly2ed to yield the diisocyanate (36). 

Abbreviations SB334867A, 1-(2-methyylbenzoxanzol-6-yl)-3-[1,5]naphthyridin-4-yl-urea hydrochloride SB408124, 1-(6,8-difluono-2-methy l-qu in ol in -4-y I )-3-(4-di methyl am ino-ph eny I )-urea aACT-078573 (Brisbare-Roch etal. Nat Med, 2007)... 

Quinine and its derivatives, when brought in contact with sensory nerves, produce local anesthesia. This is used clinically in the form of the more soluble and less irritant double salts, especially quinine urea hydrochloride. The anesthesia is more lasting than with other local anesthetics it may persist for several days. This is indeed due to necrosis of the axis cylinders and sheaths, with subsequent regeneration. However, the concentrations above 0.25% sometimes produce considerable irritation, edema, and fibrous indurations and above 1% there may be sloughing. Its employment has therefore greatly diminished, although some clinicians consider these fears as exaggerated. 

SYNS AMIDOUREA HYDROCHLORIDE AMINO-UREA HYDROCHLORIDE O CARBAMYLHYDRAZINE HYDROCHLORIDE CH HYDRAZINECARBOX-A.MIDE MONOHYDROCHLORIDE... 

Direct introduction of the carboxyl group into an aromatic ring is accomplished with urea hydrochloride, phosgene, oxalyl chloride, or carbon dioxide. Carboxylation of benzene is effected in 15-58% yields by treating with liquid phosgene and aluminum chloride. No catalyst is required in the conversion of dimethylaniline and phosgene to p-dimethyl-aminobenzoic acid (50%). 9-Anthroic acid (67%) is prepared from anthracene by heating to 240° with oxalyl chloride and nitrobenzene. ... 

Methyl Allophanate. Three hundred five milliliters of methyl chlorocarbonate (4.0 mols) and 480 g. of finely powdered urea (8.0 mols) are placed in a 2-1. standard-taper round-bottomed flask equipped with a 60-cm. reflux condenser. The mixture is heated on a steam bath for 90 minutes. Four hundred milliliters of water is added to the warm reaction cake to decompose any unreacted chlorocarbonic ester and to remove by solution both unchanged urea and urea hydrochloride, t Methyl allophanate remains behind as a relatively water-insoluble residue. The suspension is filtered and the white product washed with three 250-ml. portions of water, then with 95% ethanol (two 250-ml. portions), and finally with 500 ml. of ethyl ether. It is air-dried. The yield of product will vary from 227 to 274 g. (48 to 58%). The product thus obtained is pure enough to use as the starting material for other reactions. It can be further purified by recrystallization from hot water using 27.5 ml. of water per gram of compound (85% recovery m.p. 215 to 216° with decomposition). 

Butanol solutions of urea hydrochloride (137), urea oxalate (131), or anthraquinone (137) and hydrochloric acid yield characteristic brown-black spots with ketohexoses and their methyl derivatives. 

Uranyl acetate dihydrate Urazole Urea Urea hydrochloride Urea nitrate... 

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