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Urea Delivery System

In addition to the SCR catalyst system (DOC, SCR, ASC, mixer) and the DPF, the other main components of the system are the urea delivery system, comprising the storage tank (DEF tank) and sensors, the heated delivery line, pump, and... [Pg.14]

Pulmonary delivery currently represents the most promising alternative to parenteral delivery systems for biopharmaceuticals. Delivery via the pulmonary route moved from concept to reality in 2006 with the approval of Exubera, an inhalable insulin product (Chapter 11). Although the lung is not particularly permeable to solutes of low molecular mass (e.g. sucrose or urea), macromolecules can be absorbed into the blood via the lungs surprisingly well. In fact, pulmonary... [Pg.71]

Bundgaard, H. and Johansen, M., Prodrugs as drug delivery systems. X. N-Mannich bases as novel pro-drug candidates for amides, imides, urea derivatives, amines and other NH-acidic compounds. Kinetics and mechanisms of decomposition and structure-reactivity relatioaships. Arch. Pharm. Cheni. Sci. Ed.. 8, 29, 1980. [Pg.287]

Fig. 26 Cross-sectional view of a bioerosion-regulated hydrocortisone delivery system, a feedback-regulated drug delivery system, showing the drug-dispersed monolithic bioerodible polymer matrix with surface-immobilized ureases. The mechanism of release and time course for the urea-activated release of hydrocortisone are also shown. (From Ref > 1)... Fig. 26 Cross-sectional view of a bioerosion-regulated hydrocortisone delivery system, a feedback-regulated drug delivery system, showing the drug-dispersed monolithic bioerodible polymer matrix with surface-immobilized ureases. The mechanism of release and time course for the urea-activated release of hydrocortisone are also shown. (From Ref > 1)...
Of course, insulin release is not the unique target in the delivery field. Indeed, for example, Ishihara and coworkers [47] match the problem of urea release using a non-erod-ible membrane. The system is constituted by a pH-sensitive membrane (copolymerization of 4-carboxyacryIanilide and methacrylate) sandwiched among a manbrane containing urease immobilized in free radically cross-linked... [Pg.422]

Figure 8.18 (a) An example of folic acid conjugated with PU, using LDI, and 1,5-pentane diol based PU-urea system, (b) PU-conjugated anticancer drug (oxaplatin) delivery to specific lactose receptor, overexpressed in cancer cells. Lactobionic acid (targeting moiety). [Pg.238]

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